Jejum intermitente versus restrição calórica contínua: comparação de desfechos metabólicos em adultos com sobrepeso ou obesidade
DOI:
https://doi.org/10.47224/revistamaster.v11i21.875Keywords:
Jejum intermitente; Restrição calórica; Obesidade; Metabolismo; Perda de peso.Abstract
Abstract
Obesity and overweight are major global public health concerns, associated with metabolic alterations such as insulin resistance, dyslipidemia, and systemic inflammation. In this context, dietary strategies such as intermittent fasting (IF) and continuous caloric restriction (CCR) have been widely investigated. This study aimed to compare the effects of these interventions on metabolic outcomes in adults with overweight or obesity. This is an integrative literature review conducted according to PRISMA 2020 guidelines, with searches performed in PubMed, Scopus, BVS, and SciELO databases, including clinical trials published between 2020 and 2025. A total of 10 studies were included, evaluating outcomes such as body weight, body composition, glycemic profile, lipid profile, inflammatory markers, and insulin sensitivity. The findings showed that both strategies promote significant weight loss, with no consistent differences between them, indicating that energy deficit is the main determinant of this effect. However, some IF protocols demonstrated additional benefits, including greater reductions in visceral fat, triglycerides, and C-reactive protein in populations with metabolic syndrome and type 2 diabetes. On the other hand, no additional metabolic benefits of fasting were observed in the absence of energy restriction. In conclusion, IF is an effective and viable alternative to CCR, presenting similar metabolic outcomes, and the choice of strategy should be based on adherence and individual characteristics.
Keywords: Intermittent fasting; Caloric restriction; Obesity; Metabolism; Weight loss.
Downloads
References
ARCIERO, Paul J. et al. Intermittent fasting and protein pacing are superior to caloric restriction for weight and visceral fat loss. Obesity, Silver Spring, v. 31, supl. 1, p. 139–149, 2023. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/oby.23660 . Acesso em: março de 2026.
DHIEB, Nesrine et al. Comparative effects of 16:8 intermittent fasting and continuous caloric restriction on metabolic syndrome components in obese women: a non-randomized controlled clinical trial. La Tunisie Médicale, Tunis, v. 103, n. 8, p. 1116–1121, 2025. Disponível em: https://latunisiemedicale.com/index.php/tunismed/article/view/5777 . Acesso em: março de 2026.
ENRÍQUEZ GUERRERO, A. et al. Intermittent fasting and continuous caloric restriction: effects on body composition and lipid profile. Revista de Nutrición Clínica y Metabolismo, Bogotá, v. 3, n. 2, p. 91–102, 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33293678/. Acesso em: março de 2026.
EZZATI, M. et al. Intermittent fasting and continuous energy restriction have comparable effects on insulin sensitivity and glycemic control. Nutrition, Metabolism & Cardiovascular Diseases, Amsterdam, v. 32, n. 10, p. 2394–2403, 2022. Disponível em: https://pubmed.ncbi.nlm.nih.gov/30646030/. Acesso em: março de 2026.
HAMSHO, A. et al. Intermittent fasting versus continuous caloric restriction under isocaloric conditions: effects on body composition, insulin resistance and lipid profile. Clinical Nutrition, Edinburgh, v. 43, n. 1, p. 45–56, 2024. Disponível em: https://pmc.ncbi.nlm.nih.gov/articles/PMC9099935/ . Acesso em: março de 2026.
HUA, X. et al. Intermittent fasting for obesity and cardiometabolic health: an umbrella review of systematic reviews and meta-analyses. Frontiers in Nutrition, Lausanne, v. 11, p. 1298743, 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/38500840/ . Acesso em: março de 2026.
INGERSEN, Arthur et al. Metabolic effects of alternate-day fasting in males with obesity with or without type 2 diabetes. Frontiers in Physiology, Lausanne, v. 13, p. 1061063, 2022. Disponível em: https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.1061063/full. Acesso em: março de 2026.
KHALAFI, M. et al. Effects of intermittent fasting versus continuous energy restriction on body composition and metabolic outcomes: a systematic review and meta-analysis of randomized controlled trials. Nutrition Reviews, Oxford, v. 82, n. 2, p. 123–138, 2024. Disponível em: https://pubmed.ncbi.nlm.nih.gov/33293678/ . Acesso em: março de 2026.
LIU, D. et al. Calorie restriction with or without time-restricted eating in weight loss. New England Journal of Medicine, v. 386, n. 16, p. 1495–1504, 2022. Disponível em: https://www.nejm.org/doi/full/10.1056/NEJMoa2114833 . Acesso em: março de 2026.
MENG, Y. et al. Effects of intermittent fasting on lipid profile: a systematic review and meta-analysis. Nutrition Journal, London, v. 19, n. 1, p. 1–12, 2020. Disponível em: https://pubmed.ncbi.nlm.nih.gov/32428841/ . Acesso em: março de 2026.
NAGOEVA, A. et al. Intermittent fasting versus continuous calorie restriction in adults with obesity and cardiometabolic comorbidities. Nutrients, Basel, v. 17, n. 2, p. 455, 2025. Disponível em: https://pmc.ncbi.nlm.nih.gov/articles/PMC9099935/ . Acesso em: março de 2026.
PARVARESH, R. et al. Modified alternate-day fasting in adults with metabolic syndrome: effects on anthropometric and metabolic outcomes. Journal of Diabetes & Metabolic Disorders, Tehran, v. 18, n. 1, p. 37–45, 2019. Disponível em: https://pubmed.ncbi.nlm.nih.gov/31779987/ . Acesso em: março de 2026.
PAVLOU, V. et al. Effect of time-restricted eating on weight loss in adults with type 2 diabetes: a randomized clinical trial. JAMA Network Open, v. 6, n. 10, e2339337, 2023. Disponível em: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2811116 . Acesso em: março de 2026.
PINTO, Ana M. et al. Intermittent energy restriction is comparable to continuous energy restriction for cardiometabolic health in adults with central obesity: a randomized controlled trial: the Met-IER study. Clinical Nutrition, Edinburgh, v. 39, p. 1753–1763, 2020. Disponível em: https://www.clinicalnutritionjournal.com/article/S0261-5614(1930296-1/abstract). Acesso em: março de 2026.
SILES-GUERRERO, P. et al. Intermittent fasting compared with continuous calorie restriction for weight loss and body composition: systematic review and meta-analysis. Obesity Reviews, Oxford, v. 25, n. 3, e13642, 2024. Disponível em: https://pmc.ncbi.nlm.nih.gov/articles/PMC9099935/ . Acesso em: março de 2026.
SUNDFØR, T. M. et al. Effectiveness of intermittent versus continuous energy restriction on weight loss, weight maintenance and cardiometabolic risk: a 1-year randomized controlled trial. British Journal of Nutrition, Cambridge, v. 120, n. 2, p. 209–220, 2018. Disponível em: https://pubmed.ncbi.nlm.nih.gov/29778565/ . Acesso em: março de 2026.
TEMPLEMAN, Iain et al. A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults. Science Translational Medicine, Washington, v. 13, n. 598, p. eabd8034, 2021. Disponível em: https://www.science.org/doi/10.1126/scitranslmed.abd8034 . Acesso em: março de 2026.
ZHANG, Y. et al. Effects of intermittent fasting versus continuous caloric restriction on weight loss and metabolic risk factors. Journal of Translational Medicine, London, v. 20, n. 1, p. 1–12, 2022. Disponível em: [ ]. Acesso em: março de 2026.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Revista Master - Ensino, Pesquisa e Extensão
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Política para Periódicos de Acesso Livre
Autores que publicam nesta revista concordam com os seguintes termos:
a) A licença desses direitos autorais abrange o direito exclusivo da Revista Master - Ensino, Pesquisa e Extensão para reproduzir, publicar e distribuir o artigo,
nacional e internacionalmente, incluindo reimpressões, traduções, reproduções fotográficas, microformas, formulários eletrônicos (offline, on-line) ou qualquer outra reprodução de natureza similar.
b) O (s) autor (es) aprovam que o manuscrito não pode ser retirado ou reenviado para qualquer outro Jornal/Revista enquanto a avaliação pelos pares estiver em andamento. Após aprovado o manuscrito, um autor pode auto-arquivar uma versão de seu artigo em seu próprio site e/ou em seu repositório institucional.
c) O (s) autor (es) declaram que são integralmente responsáveis pela totalidade do conteúdo da contribuição e que a Revista Master - Ensino, Pesquisa e Extensão e o corpo editorial da Revista Científica do estão expressamente isentos de qualquer responsabilidade sobre o conteúdo do artigo, métodos, técnicas e resultados de sua pesquisa, tendo, assim, finalidade meramente informativa e educativa.
d) Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
