A Estratégias para Interferir no Processo de Envelhecimento: Um Foco em Telomerase e Intervenções Biomoleculares
Telomerase e Envelhecimento Celular
DOI:
https://doi.org/10.47224/revistamaster.v10i20.672Keywords:
Telomerase, Senescência celular, EnvelhecimentoAbstract
INTRODUCTION: Aging is a multifactorial process involving cellular and molecular changes that lead to the progressive functional loss of organ systems. Telomerase, the enzyme responsible for preserving telomere integrity, has gained prominence as a potential therapeutic target for delaying aging. OBJECTIVE: To explore biomolecular strategies, with an emphasis on telomerase, that may interfere with the aging process. MATERIALS AND METHODS: This is an integrative literature review, surveying studies from 2013 to 2024 in the PubMed, Web of Science, Cochrane Library, and Embase databases. RESULTS: Articles demonstrating the positive effects of telomerase activation, as well as stem cell interventions, epigenetic modulation, and lifestyle strategies as effective tools in combating aging, were selected. CONCLUSION: Strategies targeting telomerase modulation show promise for extending longevity with quality, but further clinical research is needed to validate the efficacy and safety of these approaches in humans.
Keywords: Aging. Telomerase. Telomeres. Longevity. Cellular senescence.
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